Just ran a Paranoia one-shot using The Sprawl. It was hilariously awesome. I had the Service Groups act as the Corporations, Secret Societies as Threats, and gave each player directives for both. I started them out with no stats, and let them assign their attributes as they played. When they got an advance, they could buy a move from one of the playbooks. I re-fluffed cybernetics as mutations, and gave everyone a random one for “free”. Pretty much everything else fit perfectly.
It probably helps that I run my Paranoia games semi-seriously (if you are familiar the terms, about halfway between Classic and Straight/Dark). I think I might do a full blown campaign of it.